Bio artificial kidney comes a step closer

Scientists from the Netherlands said they have made an important advance towards creating a functional bio artificial kidney that could one day replace the need for dialysis or transplantation in the millions of patients with kidney failure.

“The strategies and methods of this work could be relevant to the development of other bio artificial organs, such as a bio artificial liver or bio artificial pancreas, and organs on chips — such as a kidney on chip, a lung on chip, or a liver on chip,” said Dimitrios Stamatialis, from the University of Twente in the Netherlands.

A key requirement for bio artificial kidney is the formation of a “living membrane” that consists of a tight kidney cell layer on artificial membrane surfaces and can transport molecules from one side to the other.

In a paper presented at American Society of Nephrology (ASN) Kidney Week 2016 at McCormick Place in Chicago, Illinois, the researchers achieved this using conditionally immortalised human renal proximal tubular epithelial cells (ciPTECs) on polyether sulfone-based hollow fiber membranes.

They demonstrated that the cell monolayer is indeed functional as a living membrane.

“This study shows the successful development of a living membrane consisting of a reproducible ciPTEC monolayer on hollow fiber membranes, an important step towards the development of a bio artificial kidney device,” Stamatialis said.